Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation.

Biol Open · 2016 · PMC4920199 · PMID 27170255

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highly significantno p-value reported

Methylation increases and changes in expression were highly significant and reproducible either by using multiple distinct sgRNA combinations in the case of CDKN2A or at the clonal levels as observed for Cdkn1a .

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