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Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth.

Cell Rep · 2016 · PMC4920917 · PMID 27292643

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a slight trendno p-value reported
Interestingly, Mad2 did not further increase the high number of structural variants observed in Her2 mammary tumors but caused a slight trend toward whole chromosome gains and losses.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.