highly significantp < 0.001
The quantitative analysis of fluorescence intensities correlates with the priming effect observed on the Aβ-induced Ca 2+ response: the fluorescence intensity in cells chronically incubated with Aβ 1–42 was not significantly different from the fluorescence measured in control cells, while the effect of previous chronic incubation on a subsequent acute Aβ 1–42 application was highly significant ( p < 0.001, Fig. 6G ).