Pubertal development in healthy children is mirrored by DNA methylation patterns in peripheral blood.

Importantly, the core sets originating from CpGs associated with pubertal age and reproductive hormones, respectively, showed a highly significant overlap (p-value: < 0.0001; Fig. 2c ). 52 CpGs showed association to both reproductive hormones and pubertal age ( Supplementary Table 6 ) and included 5 (10%) and 6 (12%) CpGs in the proximity of the genes TRIP6 and KCNAB3 , respectively.

also in 132,142 other papers