0 −6 , associated with THY1 , COL4A2 , CYR61 , and FN1 ), cell motility (GO:0048870, P = 6.6 × 10 −6 , associated with CTHRC1, VCAN, THBS1, PLAU , and ITGB2 ), and ECM-receptor interaction (KEGG:04512, P = 2.0 × 10 −6 , associated with collagens, TNC , FN1 , CD36 , laminins, and thrombospondins) as highly significant biological processes enriched among the overexpressed genes.
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Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression.
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