Occupancy of pramipexole (Sifrol) at cerebral dopamine D2/3 receptors in Parkinson's disease patients.

Slifstein et al., 2010 ), the contrast between ON and OFF pramipexole was highly significant (p = 0.0004), and would survive much more stringent statistical criteria.

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On-Sifrol there was significant (p ˂ 0.01) occupancy at [ 18 F]fallypride binding sites in globus pallidus (8%) thalamus (9%) and substantia nigra (19%), as well as marginally significant occupancy in frontal and temporal cortex of patients.

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