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Role of IL-10-producing regulatory B cells in modulating T-helper cell immune responses during silica-induced lung inflammation and fibrosis.

Sci Rep · 2016 · PMC4926212 · PMID 27354007

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an increasing trendno p-value reported
There also is an increasing trend toward younger populations developing silicosis, which results in a heavy burden to human health and national health care systems 1 .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.