highly significantp < 0.001
Discriminant function analysis revealed distinct microbiota populations in patients and controls in both countries based on bacterial genera ( p = 0.022), with Norwegian patients displaying highly significant differences in intestinal microbiota compositions compared to Norwegian controls ( p < 0.001), typified by significant variations in Firmicutes populations, with a 50-fold decrease ( p = 0.00001) in the Firmicutes genera Holdemania and a 20-fold increase ( p = 0.003) in Lactonifactor.