Espindolol for the treatment and prevention of cachexia in patients with stage III/IV non-small cell lung cancer or colorectal cancer: a randomized, double-blind, placebo-controlled, international multicentre phase II study (the ACT-ONE trial).

J Cachexia Sarcopenia Muscle · 2016 · PMC4929828 · PMID 27386169

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a numerical trendno p-value reported

These changes showed a numerical trend towards benefit but were not statistically significant between high‐dose and placebo groups in either the mITT population ( P = 0.56) or ITT population ( P = 0.071) but certainly suggest a preservation of fat mass despite ongoing cachexia.

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