Guidelines for the Diagnosis and Treatment of Chronic Functional Constipation in Korea, 2015 Revised Edition.

115 , 118 – 127 A meta-analysis concluded that PEG treatment resulted in a highly significant increase in defecations per week over placebo. 128 In particular, a meta-analysis involving 10 RCTs found that PEG was better than lactulose with respect to the outcomes of stool frequency per week, form of stool, relief of abdominal pain, and the need for additional products. 129 PEG is poorly absorbed systemically, and does not appear to be associated with an increased risk of malformations in pregnant women. 130 25.

also in 132,142 other papers