Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1.

For the 100 top-ranked exposure-group differentially methylated positions, there was a highly significant negative correlation between exposure-group DNA methylation differences and effect sizes at the same probes for both IQ ( r =−0.82, P =4.48 × 10 −25 , Supplementary Figure 6 ) and ToM ( r =−0.89, P =2.23 × 10 −35 , Figure 3a ).

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