DNMT1 was also less expressed in samples characterized by an increased amount of neutrophils, while DNMT3B showed an increasing trend with increasing number of platelets.
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Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study.
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The sentences
Results show that the differences between the three classes of samples remained highly significant even when several variables that associated with interindividual variations in DNMT1 mRNA expression were taken into account.
The stratification of data for age and gender revealed that adjustment for batches mainly affected the upregulation of DNMT1 in the last age class obtained with unadjusted data, while a decreasing trend characterized both uncorrected and corrected data in age groups up to 64 years (Fig.