Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response.

Among probe sets exhibiting negative fold changes of ≥1.5, this analysis identified highly significant associations with STAT3 (p-value of overlap with reference set = 2.5×10 −13 ), OSM (p = 6.2×10 −9 ), IL6 (p = 1.2×10 −7 ) and other components of STAT3-dependent signaling pathways including cytokines (e.g., leukemia inhibitory factor [LIF], p = 8.2×10 −8 , and granulocyte colony-stimulating factor [GCSF], p = 8.4×10 −7 ), growth factors (e.g., hepatocyte growth factor, p = 2.2×10 −5 , and epidermal growth factor, p = 2.6×10 −4 ) and receptors (e.g., IL10 receptor α, p = 1.2×10 −6 , and IL6ST, p = 1.2×10 −4 ).

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