Relationship Between Low-Density Lipoprotein Cholesterol, Free Proprotein Convertase Subtilisin/Kexin Type 9, and Alirocumab Levels After Different Lipid-Lowering Strategies.

Effects on Alirocumab (Pharmacokinetics) When comparing alirocumab plus ezetimibe versus alirocumab plus placebo, total alirocumab C max values did not differ statistically (mean [SD] C max , 21.9 [8.9] versus 24.3 [8.6] mg/L; point estimate: 0.92 [90% CI 0.78–1.09]), with a nonsignificant trend toward lower AUC D57–85 in the alirocumab plus ezetimibe treatment group (364 [143] versus 445 [189] mg·day/L; point estimate: 0.85 [0.70–1.03]), suggesting slightly faster clearance of alirocumab in this group.

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