Again, the difference between translocations and Contr1 (0.161 ± 0.031) increased from non-significant to highly significant ( P -value 4.3 × 10 −99 ) when moving from the flanking to the middle sections (Table 3 and Supplementary Table S1B).
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Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences.
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These differences cannot be explained by end-effects alone, since the P -values between translocations and controls (which are expected to cancel out end-effects) strengthened from non-significant or barely significant (0.0028) to 8.1 × 10 −133 when shifting from the left (or right) to the middle sections (Table 3 and Supplementary Table S1B).