In this light, it may be significant that in pull down assays, nsp1β has been shown to interact with rpS14 ( 34 ), a protein immediately adjacent to a component (rpS3) of the putative ribosome-associated mRNA unwinding activity ( 13 ) and PCBP1 is known to interact with RACK1 ( 41 ), a ribosome-associated protein located close to the mRNA entry channel.
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A novel role for poly(C) binding proteins in programmed ribosomal frameshifting.
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