Identification of cyclins A1, E1 and vimentin as downstream targets of heme oxygenase-1 in vascular endothelial growth factor-mediated angiogenesis.

However, the changes in VEGF-mediated cytoprotection seen following the inclusion of ZnPPIX or the depletion of HO-1 failed to reach significance, so distinguishing the protective response from EC proliferation ( Supplementary Figure 1E and Fig. 1C ).

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