Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.

Considering the increasing translation of 13 C MRS of hyperpolarized [1- 13 C] pyruvate to the clinic, our findings are highly significant for the proper interpretation of DNP-MR imaging data from brain tumor patients and point to an unexpected metabolic imaging signature of mutant IDH1 tumors. 13 C MRS of hyperpolarized [1- 13 C] pyruvate must thus be used strategically to interrogate tumor type alongside other imaging modalities. 2

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