SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells.

In each cell line, SI113, as single agents, significantly reduced the number of viable cells, as expected, whereas the effect of the sole H 2 O 2 was barely significant, somehow comparable to the effect of the single radiation treatment.

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