Prognostic microRNA signatures derived from The Cancer Genome Atlas for head and neck squamous cell carcinomas.

The expression levels of these six miRNAs were then combined to create a single prognostic model as described previously 8 : S = 2.62 E miR − 24 − 3 p + 3.16 E miR − 31 − 5 p + 2.45 E miR − 193 b − 3 p − 2.69 E miR − 26 b − 5 p − 3.34 E miR − 142 − 3 p − 2.81 E miR − 146 a − 5 p We examined each miRNA individually with TCGA data and found that two miRNAs were significantly associated with survival, two miRNAs maintained borderline significance ( P < 0.1), and two miRNAs was not found to be significant ( P > 0.1) (Fig. 1 A).

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