Indeed, neonate EED Smo 2cKO mice exhibited a highly significant decrease in the number of Merkel cells formed when compared to control and EED cKO epidermis, as in the Smo cKO ( Fig 7A and 7B ).
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Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development.
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