This was significantly increased with stimulation by the pro‐fibrogenic cytokine TGFβ1 (56 ± 6.8%; p < 0.05) and, although bFGF enhanced the proportion of cells expressing Fn14, this did not achieve significance (57% ± 9.3%).
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Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation.
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