White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration.

Independent association of white matter hyperintensities and APOE status with cerebral amyloid The finding that WMH and APOE ε4 carrier status are both independently associated with amyloid, and that WMH volume is not associated with APOE implies that vascular burden increases the risk for cerebral amyloid over and above this highly significant genetic risk.

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