<i>OPG</i> rs2073617 polymorphism is associated with upregulated OPG protein expression and an increased risk of intervertebral disc degeneration.

Exp Ther Med · 2016 · PMC4950610 · PMID 27446264

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may be significantno p-value reported

Furthermore, the serum levels of OPG were significantly higher in IDD patients with TT, TC and CC genotypes at the OPG rs2073617 locus, as compared with the control group (P<0.05), which suggested that TT, TC and CC genotypes may be significant risk factors for IDD development and that upregulated serum levels of OPG are correlated with IDD risk.

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