Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma.

Oncotarget · 2016 · PMC4951274 · PMID 26933996

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP < 0.001actually significant

We observed a highly significant upregulation of long and very long chain ceramides (C16-C24) in the serum of patients with HCC as compared to patients with cirrhosis ( P < 0.001).

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a positive trendno p-value reported

C16Cer levels showed a positive trend to correlate with higher BCLC stages, though no significant association of serum C16Cer and BCLC stage was identified in our study ( Supplementary Figure 1C ).

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