However, as in the Drosophila gut, polysome formation was not perfectly correlated with the incorporation of 35 S radio-labeled amino acids into proteins, because we detected a highly significant 44% reduction in incorporation rate in muscle and a 19%, although non-significant, reduction in the liver of Irs1 knockout mice ( Fig. 2b ).
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Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice.
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