highly significantp = 0.001
Although resistance between each year was not significantly different, when comparing the resistant rate between 2009 and 2014 it was highly significant (p = 0.001) with a 15.5% difference ( Fig 2 ). gyr A Mutations Mutations in levofloxacin resistant strains were present in quinolone resistance-determining region (QRDR) at positions 87 and 91.