Comparison of the HER2, estrogen and progesterone receptor expression profile of primary tumor, metastases and circulating tumor cells in metastatic breast cancer patients.

In addition, the fact that ER- and PR-positive metastases significantly were found to be of visceral origin with a positive trend also documented in primary disease allows the hypothesis that CTC release as well as their downregulation of hormonal receptors might be recognized as a resistance mechanism to adjuvant endocrine therapy.

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Interestingly, in contrast to some already published studies [ 1 – 6 , 12 – 30 ], we could show that primary tumors and their metastases showed a highly significant concordance of the expression of predictive markers.

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