Role of Osteoprotegerin and Receptor Activator of Nuclear Factor-κB Ligand in Bone Loss Related to Advanced Chronic Obstructive Pulmonary Disease.

However, although the use of oral glucocorticoids are a highly significant risk factor for osteoporosis, previous studies have shown that their predictive value is relatively poor in COPD patients.[ 42 43 ] It was also observed that the risk of developing osteoporosis in COPD patients using inhaled corticosteroids was almost the same as those not using inhaled corticosteroids.[ 44 ] Finally, in this study, we did not perform a multivariate linear regression analysis to determine the independent factors associated with bone loss due to the relatively small sample size.

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