We found a statistical trend between genetic risk factors for MS and earlier age at MS first symptoms, consistent with one previous report. 9 Because there was no association between menarcheal age and age at MS onset in another large study, 6 further cohorts are required to validate our observations and to assess the role of regional or epochal differences in menarcheal age and delay in MS diagnosis.
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Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset.
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