Other diplotypes containing at least one copy of haplotype C (mutations at aa96S and nt555T) had a low frequency of occurrence (<1%); therefore, individually these less frequent diplotypes may not be significant for CWD resistance but they could play a vital role in decreasing population-level susceptibility by increasing the frequency of the C haplotype over time through inheritance (i.e. herd immunity).
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Prion protein gene sequence and chronic wasting disease susceptibility in white-tailed deer (Odocoileus virginianus).
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