Barely Significant
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Impact of the Daily Use of a Microcrystal Hydroxyapatite Dentifrice on De Novo Plaque Formation and Clinical/Microbiological Parameters of Periodontal Health. A Randomized Trial.

PLoS One · 2016 · PMC4965058 · PMID 27467683

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failed to reach significanceno p-value reported
However changes in bacterial counts observed at the interproximal sites also failed to reach significance after professional debridement (visit 3 to visit 4).

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