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Differential Frequency of CD8+ T Cell Subsets in Multiple Sclerosis Patients with Various Clinical Patterns.

PLoS One · 2016 · PMC4965085 · PMID 27467597

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an increasing trendno p-value reported
Besides these studies, Becher B, et al [ 18 ] also observed an increasing trend in the proportion of peripheral blood CD8 + T-cell subsets expressing IFN-γ in SPMS patients.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.