Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.

Whereas a highly significant 70% reduction in Map4k4 gene expression was observed in islets and a similar reduction in Map4k4 protein expression was observed in immunoblots of whole pancreata that were isolated from M4K4 iKO mice ( Fig. 4 , A and B ), no significant changes were observed in islet insulin ( Ins1 ) or glucagon ( Gcgn ) mRNA levels, although a trend to a reduction in Ins2 mRNA levels were observed ( Fig. 4 A ).

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