marginally significantP =0.06
In 2012, a study of the Tunisian population including 438 breast cancer cases and 332 controls found that rs763110 had a marginally significant association with lymph node-negative status (OR =0.53, P =0.06; OR =0.73, P =0.07, respectively). 25 However, it is demonstrated that the C allele of the rs763110 SNP may be associated with a lower risk of lymph node metastasis and a higher occurrence of HER2-positive breast cancers.