Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver Resection.

PLoS Genet · 2016 · PMC4966938 · PMID 27472274

Europe PMC DOI

hedged sentence

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

borderline significantP = 0.08so close (0.05 < p ≤ 0.1)

For three-year PFS, the prognostic association of intra-patient heterogeneity remained borderline significant (multivariable HR = 0.5 [0.2–1.1], P = 0.08) in a multivariable model with genomic complexity and synchronous versus metachronous metastases.

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