Hepatocyte Nuclear Factor 4α (HNF4α) Is a Transcription Factor of Vertebrate Fatty Acyl Desaturase Gene as Identified in Marine Teleost Siganus canaliculatus.

Compared with the wild type D2, mutation of binding sites for NF-1, NF-Y, HNF4α and SRE caused a highly significant decrease in transcriptional activity, while the effect of GATA-2 and C/EBP mutation was also significant ( P < 0.05) ( Fig 4 ).

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