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An upright eyedrop bottle: accuracy, usage of excess drops, and contamination compared to a conventional bottle.

Clin Ophthalmol · 2016 · PMC4968848 · PMID 27555747

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a decreasing trendno p-value reported
23 Contamination rates with the conventional bottle did not show a decreasing trend as trials progressed.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.