Degradability, biocompatibility, and osteogenesis of biocomposite scaffolds containing nano magnesium phosphate and wheat protein both in vitro and in vivo for bone regeneration.

The results also suggested that altering the nMP content in the MWC scaffolds could adjust the degradability rate of the scaffolds, which was highly significant for bone tissue ingrowth and new bone formation. 22 It is known that the release of acidic degradation by-products from some degradable polymers could lead to inflammatory responses in vivo, and many methods have been tried to control the pH decrease during the degradation of these polymers. 23 , 24 In this study, it was found that there was gradually a decrease of pH in the solution containing WP (from 7.40 to 7.10), indicating that some acidic products (amino acids) might be produced from WP degradation during the soaking process.

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