highly significantp -values < 3.7 × 10 −15
Considering our head (252 genes) and body (1,940 genes) datasets separately, and assuming 14,000 total genes in the Drosophila genome, the number of genes that intersect between our study and three or more other sets of age-related genes is highly significant (all p -values < 3.7 × 10 −15 ).