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Inflammatory Cytokines Interleukin-1β and Tumour Necrosis Factor-α - Novel Biomarkers for the Detection of Periodontal Diseases: a Literature Review.

J Oral Maxillofac Res · 2016 · PMC4970502 · PMID 27489606

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an increasing trendno p-value reported
The prevalence demonstrates an increasing trend and a correlation with numerous comorbidities.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.