PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury.

Administration of Tm to mice caused the increases not only in hepatic PHLDA3 levels as shown in figure 2 A, but also in serum transaminase activities (ie, ALT and aspartate transaminase (AST)), and there existed a highly significant correlation ( figure 5 A).

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