marginally significantP =0.06
Additionally, we performed subgroup analysis according to specific TAs and found that the use of anti-VEGF agents significantly improved PFS (HR 0.81, 95% CI: 0.69–0.96, P =0.012) and a marginally significant PFS benefits for anti-EGFR agents (HR 0.89, 95% CI: 0.79–1.01, P =0.06).