Systemically and cutaneously distributed ectoparasiticides: a review of the efficacy against ticks and fleas on dogs.

In a field evaluation on the prevention of tick bites in dogs with a 10 % imidacloprid/50 % permethrin combination (Advantix, Bayer Animal Health, Leverkusen, Germany), it was found that treatment application once or twice monthly led to a highly significant 95.57 % reduction of the risk of Ehrlichia canis transmission in an endemic area in southern Italy [ 46 ].

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