An increasing trend for the risk of advanced neoplasm was observed in cases with high-grade dysplasia detected by colonoscopy, compared to cases with low-grade dysplasia: combined OR 1.33 (95% CI, 0.85 to 2.09) and combined HR 1.69 (95% CI, 1.14 to 2.50) [ 21 , 22 , 27 ].
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