Resveratrol chemosensitizes HER-2-overexpressing breast cancer cells to docetaxel chemoresistance by inhibiting docetaxel-mediated activation of HER-2-Akt axis.

The expression status of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2/neu) is highly significant in clinical scenario due to the influence of these trios in dictating the response of breast cancer cells to the currently available chemotherapeutic agents. 1 , 2 Hormonal receptors are ideal therapeutic targets and tumors overexpressing them usually respond well to hormonal therapy. 3 On the contrary, the HER-2 overexpression is considered as a clinical dilemma, which often portends tumour aggressiveness and chemotherapeutic resistance in tumor cells.

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