The simultaneous over-expression of St14 and treatment with proHGF (Group 4) resulted in a highly significant decrease in the expression of Oct4 and Nanog than what was observed following either proHGF treatment or overexpression of St14 alone (Group 2 and Group 3) (Fig. 1 D and 1 E).
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Activation of proHGF by St14 induces mouse embryonic stem cell differentiation.
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