Laquinimod dampens hyperactive cytokine production in Huntington's disease patient myeloid cells.

Cytokine release in laquinimod‐treated non‐stimulated monocytes Monocytes from HV showed at least borderline significant evidence for an increase in Th1‐activating cytokine IL‐12 ( p = 0.062) (Figure S1) and the Th2‐activating cytokines IL‐4 ( p = 0.009) and IL‐5 ( p = 0.002) (Figure S2), after 2hPT with 1 μM laquinimod.

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IL‐4, IL‐6 and IL‐10 had differences in similar magnitude but did not reach borderline significance.

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