Prevalence of crt and mdr-1 mutations in Plasmodium falciparum isolates from Grande Comore island after withdrawal of chloroquine.

An increasing trend in the prevalence of the pfmdr - 1 wild type allele (NYD, 4.3 % in 2006–2007; and 28.7 % in 2013–2014), and a decreasing trend for pfmdr - 1 N86Y mutation (87.0 % in 2006–2007; and 40.2 % in 2013–2014) were observed in our samples.

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Similarly, with the prevalence of pfmdr - 1 N86Y reaching a peak in 2000 (78 %), there was a highly significant decline in prevalence of the pfmdr - 1 N86Y allele in 2008 in Gambia [ 18 ].

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