Barely Significant
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Motif oriented high-resolution analysis of ChIP-seq data reveals the topological order of CTCF and cohesin proteins on DNA.

BMC Genomics · 2016 · PMC4986361 · PMID 27526722

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highly significantP < 2.2x10 -16actually significant
In Additional file we present a case study (Additional file 1 : Figure S12), in which an asymmetric binding complex (the FOXA1/AR) showed a highly significant 4 bp shift between its components ( P < 2.2x10 -16 according to the Wilcoxon signed-rank test), while symmetrically binding controls show no shift (Additional file 1 : Figure S13), which gives further support to the general applicability of the analysis principle.

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